This study compares cytokine responses in male and female mice to TFEB overexpression and voluntary wheel running, revealing sex-based differences in exercise-induced inflammation.

Physiological Reports · Aug 1, 2025Peer-reviewedPhysiology

Evaluation of altered cell-cell communication between glia and neurons in the hippocampus of 3xTg-AD mice at two time points

Tabea M. Soelter, Timothy C. Howton, Elizabeth J. Wilk, Jordan H. Whitlock, Amanda D. Clark, Allison Birnbaum, Dalton C. Patterson, Constanza J. Cortés, Brittany N. Lasseigne

The paper evaluates changes in glia-neuron communication in 3xTg-AD mice hippocampus at 6 and 12 months, finding increased dysregulation and 23 AD-associated ligand-receptor pairs.

Journal of Cell Communication and Signaling · Feb 28, 2025Peer-reviewedGenomics

Skeletal Muscle TFEB Signaling Promotes Central Nervous System Function and Reduces Neuroinflammation during Aging and Neurodegenerative Disease

Ian Matthews, Allison Birnbaum, Anastasia Gromova, Amy W. Huang, Kailin Liu, Eleanor A. Liu, Kristen Coutinho, Megan McGraw, Dalton C. Patterson, Macy T. Banks, Amber C. Nobles, Nhat Nguyen, Gennifer E. Merrihew, Lu Wang, Eric Baeuerle, , Constanza J. Cortés

This study shows that enhancing skeletal muscle TFEB signaling reduces neuroinflammation and tau pathology in aging and neurodegenerative disease models.

Cell Reports · Nov 1, 2023Peer-reviewedNeuroscience