Hijacking a dedicated entorhinal-hippocampal extinction circuit to remove traumatic memory
Ze-Jie Lin, Xuefeng Gu, W. Gong, Mo Wang, Yan‐Jiao Wu, Qi Wang, Xinrong Wu, Xinyu Zhao, Michael X. Zhu, Lu‐Yang Wang, Quanying Liu, Ti‐Fei Yuan, Wei‐Guang Li, Tian‐Le Xu
This study identifies a specific LEC-vCA1 pathway that uses low gamma-band oscillations to facilitate fear extinction and shows its therapeutic potential through DBS and tACS in a PTSD mouse model.
bioRxiv · May 13, 2024 · PreprintNeuroscience