Lu‐Yang Wang

This study shows that calcium-dependent facilitation of P/Q-type calcium channels controls the polarity and magnitude of short-term synaptic plasticity in fast-spiking synapses.

The paper identifies NPY+ interneurons in the ventral hippocampus that regulate memory extinction through distinct sub-ensembles via fast and slow inhibition.

This study identifies the ARP2/3 complex as a downstream effector of mTORC1 and mTORC2 hyperactivation in PTEN-deficient neural cells, showing its inhibition can rescue disease phenotypes.

This paper identifies that N1 cassette-lacking NMDA receptors mediate ketamine's antidepressant effect by remaining blocked during neuronal firing.

The paper shows that disease-linked shank2 mutations alter condensate physical properties and composition, leading to aberrant RNA translation.

The paper determines the high-resolution structure of V-ATPase in native synaptic vesicles using cryo-EM, revealing interactions with cholesterol and synaptophysin.

This study identifies a specific LEC-vCA1 pathway that uses low gamma-band oscillations to facilitate fear extinction and shows its therapeutic potential through DBS and tACS in a PTSD mouse model.

This study identifies glutamate as a co-agonist for acid-sensing ion channels (ASICs) that worsens ischemic brain damage, and presents a small molecule inhibitor that targets this interaction without affecting NMDARs.

The paper shows that forgetting of extinction memory involves a dynamic shift in the connectivity of engram circuits between the mPFC, BLA, and vHPC.

This study shows that gamma-Protocadherins are essential for the survival of GABAergic interneurons during development, preventing excessive apoptosis and ensuring proper inhibitory network formation.