Author

Marcel Proske

Universität UlmORCID 0000-0002-1570-7231Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Dierk NiessingiD· 2 shared Lena MolitoriD· 2 shared Sabrina Bacher· 2 shared Alejandro Varela‐RialiD· 1 shared Anke BuschiD· 1 shared Anna CroisiD· 1 shared Anna Pertek· 1 shared Carolin KetteleriD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Dierk NiessingORCID

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2 papers

Recent·Most cited

PURA Syndrome-causing mutations impair PUR-domain integrity and affect P-body association

Marcel Proske, Robert Janowski, Sabrina Bacher, Hyun-Seo Kang, Thomas Monecke, Tony Köhler, Saskia Hutten, Jana Tretter, Anna Crois, Lena Molitor, Alejandro Varela‐Rial, Roberto Fino, Elisa Donati, Gianni De Fabritiis, Dorothee Dormann, , Dierk Niessing

This study shows that PURA syndrome mutations disrupt PURA's structure and P-body association, explaining full penetrance of the disease.

eLife · Jan 24, 2024Peer-reviewedMolecular Biology

Depletion of the RNA-binding protein PURA triggers changes in posttranscriptional gene regulation and loss of P-bodies

Lena Molitor, Melina Klostermann, Sabrina Bacher, Juliane Merl‐Pham, Nadine Spranger, Sandra Burczyk, Carolin Ketteler, Ejona Rusha, Daniel Tews, Anna Pertek, Marcel Proske, Anke Busch, Sarah Reschke, Regina Feederle, Stefanie M. Hauck, , Dierk Niessing

This study shows that PURA depletion affects posttranscriptional regulation and P-body formation, linking PURA Syndrome to neurodevelopmental disorders.

Nucleic Acids Research · Dec 13, 2022Peer-reviewedMolecular Biology