Author

Thomas Monecke

Universität UlmORCID 0000-0003-3748-710XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Organism:yeast· 2 Organism:Drosophila· 1 Organism:human· 1

Frequent Co-Authors

Dierk NiessingiD· 4 shared Dorothee DormanniD· 2 shared Janosch HennigiD· 2 shared Michael SattleriD· 2 shared Robert JanowskiiD· 2 shared Wieland Mayer· 2 shared Alejandro Varela‐RialiD· 1 shared André P. GerberiD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersBiochemistry

Dierk NiessingORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Two components of the early ASH1 mRNA transport machinery undergo PUN motif-dependent liquid-liquid-phase separation

Wieland Mayer, Thomas Monecke, Juliane Bethmann, Henning Urlaub, Dierk Niessing

The paper shows that Loc1p and She2p undergo PUN motif-dependent liquid-liquid-phase separation, which is essential for early ASH1 mRNA transport.

bioRxiv · Jan 20, 2026 · PreprintBiochemistry

A direct interaction between the RNA-binding proteins Staufen and Tm1-I/C regulates oskar mRNP composition and transport

Thomas Gaber, Julia Grabowski, Bernd Simon, Thomas Monecke, Tobias D. Williams, Vera Roman, Jeffrey Alan Chao, Janosch Hennig, Anne Ephrussi, Dierk Niessing, Simone Heber

The paper shows Staufen directly interacts with Tm1 to regulate oskar mRNA transport by modulating kinesin-1 activity in Drosophila oocytes.

bioRxiv · Dec 18, 2024 · PreprintMolecular Biology

Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation

Annika Niedner, Thomas Monecke, Janosch Hennig, Melina Klostermann, Mario Hofweber, Elena Davydova, André P. Gerber, Irina Anosova, Wieland Mayer, Marisa Müller, Roland G. Heym, Robert Janowski, Jean‐Christophe Paillart, Dorothee Dormann, Kathi Zarnack, , Dierk Niessing

This study identifies PUN motifs in yeast Loc1p that cooperate to catalyze RNA folding and drive phase separation, suggesting a role in RNA and DNA-related processes across species.

Nucleic Acids Research · Nov 15, 2024Peer-reviewedBiochemistry

PURA Syndrome-causing mutations impair PUR-domain integrity and affect P-body association

Marcel Proske, Robert Janowski, Sabrina Bacher, Hyun-Seo Kang, Thomas Monecke, Tony Köhler, Saskia Hutten, Jana Tretter, Anna Crois, Lena Molitor, Alejandro Varela‐Rial, Roberto Fino, Elisa Donati, Gianni De Fabritiis, Dorothee Dormann, , Dierk Niessing

This study shows that PURA syndrome mutations disrupt PURA's structure and P-body association, explaining full penetrance of the disease.

eLife · Jan 24, 2024Peer-reviewedMolecular Biology