Dierk Niessing

The study shows the N-terminal extension of AtKEA1 is not essential for plastid function but contributes to potassium homeostasis.

The paper characterizes the HNSC.100 neural stem cell line, showing its ability to differentiate into major neural cell types and providing gene expression data and markers for neurobiological research.

This study identifies Pfk2p as an ATP-dependent RNA unwinding enzyme that modulates cell cycle progression by promoting translation of mitotic genes.

The paper shows that Loc1p and She2p undergo PUN motif-dependent liquid-liquid-phase separation, which is essential for early ASH1 mRNA transport.

This study reveals how VDAC1 oligomerization triggers apoptosis by exposing its N-terminal helix, which neutralizes anti-apoptotic BclxL and promotes pore formation by Bak.

The paper shows Staufen directly interacts with Tm1 to regulate oskar mRNA transport by modulating kinesin-1 activity in Drosophila oocytes.

This study identifies PUN motifs in yeast Loc1p that cooperate to catalyze RNA folding and drive phase separation, suggesting a role in RNA and DNA-related processes across species.

The paper identifies a consensus motif for She2p/3p recognition sites in yeast RNA, showing that spatial arrangement of sequence features is more important than sequence order for function.

This study shows that PURA syndrome mutations disrupt PURA's structure and P-body association, explaining full penetrance of the disease.

This study shows that PURA depletion affects posttranscriptional regulation and P-body formation, linking PURA Syndrome to neurodevelopmental disorders.

The paper reports the X-ray structure of HCV genotype 4a NS5b, an RNA-dependent RNA-polymerase, to aid in structure-based drug design.

The paper identifies and validates small-molecule inhibitors of TRMT2A that reduce polyQ aggregation and cell death in human cells.

The paper identifies the combinatorial RNA recognition code of IMP3 using an integrative approach combining SELEX-seq, iCLIP, and structural analysis.