Robert Janowski

The Conserved N-Terminal Extension of AtKEA1 Is Largely Dispensable for Plastid Function but Contributes to Potassium Homeostasis

The study shows the N-terminal extension of AtKEA1 is not essential for plastid function but contributes to potassium homeostasis.

Structural basis of apoptosis induction by the mitochondrial voltage dependent anion channel

This study reveals how VDAC1 oligomerization triggers apoptosis by exposing its N-terminal helix, which neutralizes anti-apoptotic BclxL and promotes pore formation by Bak.

Intrinsically disordered RNA-binding motifs cooperate to catalyze RNA folding and drive phase separation

This study identifies PUN motifs in yeast Loc1p that cooperate to catalyze RNA folding and drive phase separation, suggesting a role in RNA and DNA-related processes across species.

PURA Syndrome-causing mutations impair PUR-domain integrity and affect P-body association

This study shows that PURA syndrome mutations disrupt PURA's structure and P-body association, explaining full penetrance of the disease.

Structural studies of hepatitis C virus non-structural protein-5b of genotype 4a

The paper reports the X-ray structure of HCV genotype 4a NS5b, an RNA-dependent RNA-polymerase, to aid in structure-based drug design.

Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death

The paper identifies and validates small-molecule inhibitors of TRMT2A that reduce polyQ aggregation and cell death in human cells.

Combinatorial recognition of clustered RNA elementsby a multidomain RNA-binding protein, IMP3

The paper identifies the combinatorial RNA recognition code of IMP3 using an integrative approach combining SELEX-seq, iCLIP, and structural analysis.