Author

Ying‐Chih Chiang

Chinese University of Hong Kong, ShenzhenORCID 0000-0002-1585-7213Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:metagenomics· 1

Frequent Co-Authors

Lantian YaoiD· 2 shared Peilin XieiD· 2 shared Tzong-Yi LeeiD· 2 shared Anni Wang· 1 shared Cheng JiangiD· 1 shared Chi XiongiD· 1 shared Chia‐Ru ChungiD· 1 shared Dongmei SuniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioinformatics

Lantian YaoORCID

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3 papers

Recent·Most cited

Geometry-enhanced protein language modeling enables discovery of novel antibiotic resistance genes

Xingqiao Lin, Jiahui Guan, Yue Hong, Yilian Guo, Yutao Yang, Peilin Xie, Zhihao Zhao, Xingchen Liu, Yixian Huang, Yujing Ye, Yun Tang, Tzong-Yi Lee, Ying‐Chih Chiang, Li Wei, Xiangrong Liu, , Lantian Yao

GeoARG improves detection of distant antibiotic resistance genes using structural features and protein language models, uncovering 1,485 novel candidates.

bioRxiv · Apr 8, 2026 · PreprintBioinformatics

Impact of Peptide Initial Configuration and Membrane Composition on Melittin's Pore-Forming Ability under Unbiased All-Atom Molecular Dynamics Simulations

Zhihao Zhao, Yilin Guo, Jiaxiang Cai, Peilin Xie, Jiahui Guan, Lantian Yao, Yulan Liu, Chia‐Ru Chung, Tzong-Yi Lee, Ying‐Chih Chiang

This study uses molecular dynamics simulations to show that melittin's pore-forming ability depends on initial configuration and membrane composition, with lysine-7 playing a key role in pore formation.

bioRxiv · May 28, 2025 · PreprintBiochemistry

Enhanced Recognition of a Herbal Compound Epiberberine by a DNA Quadruplex-Duplex Structure

Xuan Zhan, Liping Deng, Yun Lian, Zhiyu Shu, Yunong Xu, Xinyi Mai, Manchugondanahalli S. Krishna, Rongguang Lu, Anni Wang, Shiyao Bai, Fangyu Zhou, Chi Xiong, Yingyi Xu, Jie Ni, J. Jeya Vandana, , Gang Chen

This paper investigates how epiberberine binds to a DNA quadruplex structure and shows how modifying the DNA structure enhances binding affinity, leading to a new method for extracting the compound from plant extracts.

Analytical Chemistry · Aug 2, 2024Peer-reviewedBiochemistry