Chul‐Hwan Lee

Intrauterine growth restriction is associated with adaptive hematopoietic reprogramming and selective immune rewiring in monozygotic twins

The paper identifies adaptive hematopoietic and immune reprogramming in discordant monozygotic twins with intrauterine growth restriction through transcriptomic and epigenomic analyses.

Mtf2 Safeguards Naïve Pluripotency by Restricting Trophectoderm Competence

This study identifies Mtf2 as an epigenetic barrier that maintains naive pluripotency by restricting trophectoderm competence in embryonic stem cells.

Distinct regulation of AEBP2 isoforms on PRC2 activity

The paper identifies an isoform-specific regulatory mechanism of AEBP2 on PRC2 activity, showing the long isoform inhibits PRC2 while the short isoform enhances it.

EZH1 Q571R-mediated chromatin compaction and its oncogenic potential in thyroid cancer

This study shows that the EZH1Q571R mutation enhances chromatin compaction and PRC2 activity, leading to repression of tumor suppressor genes in follicular thyroid cancer.

Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy

The paper investigates the role of EZH2 in Duchenne muscular dystrophy and shows that inhibiting EZH2 improves muscle phenotype in Dmd mutant mice when combined with glucocorticoids.

De novo HDAC3 variants leading to epigenetic machinery dysfunction are associated with a neurodevelopmental disorder

This study identifies de novo HDAC3 variants in patients with neurodevelopmental disorders and shows they cause reduced HDAC activity, disrupted protein interactions, and impaired nuclear localization.

Gain and loss of function variants in EZH1 disrupt neurogenesis timing and cause overlapping neurodevelopmental disorders

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription

The paper identifies LEDGF and HDGF2 as proteins that substitute for FACT in differentiated tissues to enable RNAPII to overcome nucleosome barriers during transcription.

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

The paper investigates how H3K27M mutations inhibit PRC2 in DIPG, revealing mechanisms of chromatin alteration and PRC2 dysfunction.

Automethylation of PRC2 fine-tunes its catalytic activity on chromatin

This study identifies PRC2 automethylation on EZH1/2 and SUZ12 as a self-activating mechanism that regulates its catalytic activity on chromatin.

Capturing the onset of PRC2-mediated repressive domain formation

The paper demonstrates a two-step mechanism of PRC2-mediated repressive domain formation through nucleation sites and long-range spreading of H3K27me2/3.