Cancer BiologybioRxivPreprint
Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells
Ting Zhao, Lingli He, Lai Ping Wong…·David T. Scadden
The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.
DOI 10.1101/2025.04.25.650293