Lingli He

FFPERescuer uses deep learning to improve gene expression reconstruction from degraded FFPE samples, achieving high accuracy and enhancing cancer subtyping.

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

This study reveals bidirectional fate transitions between myeloid-biased and lineage-balanced hematopoietic stem cells using clonal phylogenetic tracing.