David B. Sykes

Siglec-15 is found on prostate tumour cells, macrophages and osteoclasts; antibody blockade reduced macrophage immunosuppression, osteoclast formation and tumour growth in mice (CD8+ T-cell-dependent).

This study identifies Siglec-engaging sialoglycans as upregulated in prostate cancer and shows they can be targeted to suppress bone metastasis using a bisialidase.

The paper shows that IRES/Cap translation increases during hematopoietic and epithelial differentiation under normal conditions, correlating with lower stemness.

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

The paper identifies clonal Parabacteroides distasonis isolates from CD-associated gut fistulas that exhibit pathogenic traits in mouse models and show potential for transmissibility and adaptation to CD-like ileitis.

The paper identifies a point of irreversible commitment in granulocytic differentiation and shows how chromatin state dynamics and transcription factor feedback loops influence this decision.

This study shows that CAF-1 maintains myeloid lineage identity by regulating chromatin accessibility and transcription factor control during differentiation.