Sonia N. Acharya

Mutant ASXL1 Drives Transcriptional Activation and Repression in Human Hematopoiesis

This study functionally characterizes mutant ASXL1 in human hematopoietic stem cells, showing it drives transcriptional activation and repression through interactions with BRD4 and MECOM, with implications for therapy.

Epigenetic and Transcriptomic Alterations Precede Amyloidosis in the Hippocampus of the Alzheimer's Disease AppNL-G-F Knock in Mouse Model

This study identifies epigenetic and transcriptomic changes in the hippocampus and blood of an Alzheimer's mouse model before amyloidosis onset, suggesting blood methylation as a potential biomarker.

Atlas-scale Single-cell DNA Methylation Profiling with sciMETv3

The paper introduces sciMETv3, a high-throughput single-cell DNA methylation profiling method, achieving 100-fold higher cell throughput and compatibility with multimodal assays.

sciMET-cap: High-throughput single-cell methylation analysis with a reduced sequencing burden

sciMET-cap reduces sequencing burden for single-cell methylation analysis while enabling accurate cell type assignment and near-complete methylome reconstruction.