David William Ray

Population-scale molecular reconstruction of human circadian phase from blood biomarkers

The paper infers circadian phase from blood biomarkers in UK Biobank using machine learning and defines a new construct, circadian acceleration, with genetic and environmental associations.

Shared genetic basis for brain structure, insulin resistance and inflammation in schizophrenia: a colocalization study

This study identifies shared genetic loci linking schizophrenia, brain structure, insulin resistance, and inflammation through colocalization analysis.

Discovering the genetic architecture of sleep regulation: genome-wide association study of device-measured sleep traits.

This study identifies 20 genetic loci associated with sleep traits using UK Biobank data, including novel signals for REM and NREM sleep duration and sex-specific associations.

Ribosomal modification by BUD23 drives selective translational control over energy state and metabolic health

This study identifies BUD23 as a regulator of energy homeostasis by controlling translation of mitochondrial and lipogenic mRNAs, linking ribosomal modification to metabolic health.

Fibroblast-like synoviocytes orchestrate daily rhythmic inflammation in arthritis

This study shows that fibroblast-like synoviocytes' circadian clock influences daily inflammation rhythms in arthritis, with Bmal1 deletion reducing arthritis susceptibility but increasing MMP3 production.

HNF4A is required to specify glucocorticoid action in the liver

This study shows HNF4A is essential for liver-specific GR action, with HNF4A regulating GR binding sites and transcriptional response to glucocorticoids in the liver.

Re-Evaluating One-step Generation of Mice Carrying Conditional Alleles by CRISPR-Cas9-Mediated Genome Editing Technology

The paper re-evaluates the efficiency of a CRISPR-Cas9 method for generating conditional knockout alleles in mice, finding very low success rates and high rates of undesired alleles.

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

This study identifies 42 genetic loci associated with excessive daytime sleepiness and links them to phenotypic subgroups and related traits.

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Biological and clinical insights from genetics of insomnia symptoms

The paper identifies 57 genomic regions associated with insomnia symptoms, linking them to phototransduction, ubiquitination, and potential causal relationships with coronary heart disease and depression.

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

This study identifies 351 new genetic loci associated with chronotype using data from 697,828 individuals and links them to circadian biology and disease.

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

This study identifies new genetic loci associated with sleep disturbance traits and finds shared genetic links with neuropsychiatric and metabolic traits.