ImmunologyAdvanced SciencePeer-reviewed
Inhibition of KDEL receptors remodels the tumor microenvironment for robust T cell independent tumor regression
Shakti Prasad Pattanayak, Hong Wang, Belinda Willard…·Boaz Tirosh
The paper shows that inhibiting KDELR2 in tumor cells promotes tumor regression through innate immune activation, independent of T cells, and primes anti-tumor T cells for future challenges.
DOI 10.1002/advs.76148