Author

Alexandra Bergholtz

Uppsala UniversityORCID 0000-0002-1630-4442Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:metabolomics· 1

Frequent Co-Authors

Jens ErikssoniD· 3 shared Maria Letizia Di MartinoiD· 3 shared Mikael E. SelliniD· 3 shared Ana C. C. LopesiD· 2 shared Dominic‐Luc WebbiD· 2 shared Magnus SundbomiD· 2 shared Martin Löfling SkogariD· 2 shared Per M. HellströmiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersMicrobiology

Jens ErikssonORCID

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3 papers

Recent·Most cited

MicrobiologyGut MicrobesPeer-reviewedSep 12, 2026

Dual Screen for Gut Metabolites Suppressing Enterobacterial Growth and Invasiveness Reveals Structure - Activity Relationships among Anti-Infective Indoles

Alexandra Bergholtz, Weifeng Lin, Amanpreet Kaur…·Mikael E. Sellin

The paper screens gut metabolites for anti-infective activity against Salmonella and Shigella, identifying indole derivatives with structure-activity relationships affecting virulence and growth.

DOI 10.1080/19490976.2026.2728235

humanmetabolomics

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Cell BiologyCell ReportsPeer-reviewedNov 21, 2025

Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack

Jorik M. van Rijn, Ana C. C. Lopes, Finja S.V. Dienhart…·Mikael E. Sellin

This study shows that maturation of human intestinal epithelial cells reduces susceptibility to Salmonella invasion by altering actin regulation, mucin expression, and glycocalyx composition.

9 citations

humanimaging

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MicrobiologymBioPeer-reviewedMay 30, 2025

Determinants of the Divergent Salmonella and Shigella Epithelial Colonization Strategies Resolved in Human Enteroids and Colonoids

Petra Geiser, Maria Letizia Di Martino, Ana C. C. Lopes…·Mikael E. Sellin

This study compares Salmonella and Shigella colonization strategies in human enteroids and colonoids, identifying distinct virulence factor modules that drive divergent infection kinetics and epithelial colonization patterns.

8 citations

humanimaging

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