Mikael E. Sellin

Apical-Out Ileal Organoids: A Versatile Platform for Probing Gut-Nanomaterial Interactions

This study establishes human apical-out ileal organoids as a model to study gut-nanomaterial interactions, showing charge-selective uptake regulated by the glycocalyx.

Dual Screen for Gut Metabolites Suppressing Enterobacterial Growth and Invasiveness Reveals Structure - Activity Relationships among Anti-Infective Indoles

The paper screens gut metabolites for anti-infective activity against Salmonella and Shigella, identifying indole derivatives with structure-activity relationships affecting virulence and growth.

A bare host cell membrane with minimal glycocalyx is an optimal surface for targeting by virulence-primed Salmonella Typhimurium

This study identifies that a minimal glycocalyx on host cell membranes optimally facilitates Salmonella Typhimurium targeting, with glycoproteins and cholesterol playing key roles.

Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack

This study shows that maturation of human intestinal epithelial cells reduces susceptibility to Salmonella invasion by altering actin regulation, mucin expression, and glycocalyx composition.

The pcnB gene sustains Shigella flexneri virulence

The paper shows that the pcnB gene in Shigella flexneri promotes virulence by sustaining optimal levels of the virulence plasmid pINV, enhancing colonization and infection.

Matrix-M(R) adjuvant triggers inflammasome activation and enables antigen cross-presentation through induction of lysosomal membrane permeabilization

This study shows Matrix-M adjuvant induces lysosomal membrane permeabilization, enabling antigen cross-presentation and IL-1β/IL-18 secretion, which contributes to its adjuvant effect.

Determinants of the Divergent Salmonella and Shigella Epithelial Colonization Strategies Resolved in Human Enteroids and Colonoids

This study compares Salmonella and Shigella colonization strategies in human enteroids and colonoids, identifying distinct virulence factor modules that drive divergent infection kinetics and epithelial colonization patterns.

Human jejunal enteroids for studies of epithelial drug transport and metabolism

This study establishes and characterizes human jejunal enteroids for studying epithelial drug transport and metabolism, showing they recapitulate in vivo features and accurately predict drug pharmacokinetics.