Author

Ana C. C. Lopes

Uppsala UniversityORCID 0000-0002-9135-7974Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:imaging· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Jens ErikssoniD· 4 shared Maria Letizia Di MartinoiD· 4 shared Mikael E. SelliniD· 4 shared Dominic‐Luc WebbiD· 3 shared Magnus SundbomiD· 3 shared Per ArturssoniD· 3 shared Per M. HellströmiD· 3 shared Alexandra BergholtziD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCell Biology

Jens ErikssonORCID

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4 papers

Recent·Most cited

Apical-Out Ileal Organoids: A Versatile Platform for Probing Gut-Nanomaterial Interactions

Dinh Son Vo, Alina Meyer, Foteini Tzioufa, Jens Eriksson, Ana C. C. Lopes, Maria Letizia Di Martino, Wojciech Fijalkowski, James Rae, Kajsa Björner, Johan Vessby, Robert G. Parton, Hanna M. G. Barriga, Mikael E. Sellin, Per Artursson, Madlen Hubert

This study establishes human apical-out ileal organoids as a model to study gut-nanomaterial interactions, showing charge-selective uptake regulated by the glycocalyx.

bioRxiv · Oct 13, 2026 · PreprintCell Biology

Maturation of Human Intestinal Epithelial Cell Layers Fortifies the Apical Surface against Salmonella Attack

Jorik M. van Rijn, Ana C. C. Lopes, Finja S.V. Dienhart, Merve Ceylan, Nora Trinks, Jens Eriksson, Alexandra Bergholtz, Angelika Ntokaki, Rebekkah Hammar, Magnus Sundbom, Martin Löfling Skogar, Wilhelm Graf, Dominic‐Luc Webb, Per M. Hellström, Per Artursson, , Mikael E. Sellin

This study shows that maturation of human intestinal epithelial cells reduces susceptibility to Salmonella invasion by altering actin regulation, mucin expression, and glycocalyx composition.

Cell Reports · Nov 21, 2025Peer-reviewedCell Biology

Determinants of the Divergent Salmonella and Shigella Epithelial Colonization Strategies Resolved in Human Enteroids and Colonoids

Petra Geiser, Maria Letizia Di Martino, Ana C. C. Lopes, Alexandra Bergholtz, Magnus Sundbom, Martin Löfling Skogar, Wilhelm Graf, Kajsa Björner, Johan Vessby, Dominic‐Luc Webb, Per M. Hellström, Jens Eriksson, Mikael E. Sellin

This study compares Salmonella and Shigella colonization strategies in human enteroids and colonoids, identifying distinct virulence factor modules that drive divergent infection kinetics and epithelial colonization patterns.

mBio · May 30, 2025Peer-reviewedMicrobiology

Human jejunal enteroids for studies of epithelial drug transport and metabolism

Merve Ceylan, Foteini Tzioufa, Maria Letizia Di Martino, Rebekkah Hammar, Ana C. C. Lopes, Jens Eriksson, Dinh Son Vo, Magnus Sundbom, Martin Skogar, Per M. Hellström, Dominic‐Luc Webb, Maria Karlgren, Iain B. Gardner, Patrik Lundquist, Daisy Torino Hjelmqvist, , Per Artursson

This study establishes and characterizes human jejunal enteroids for studying epithelial drug transport and metabolism, showing they recapitulate in vivo features and accurately predict drug pharmacokinetics.

bioRxiv · Mar 17, 2025 · PreprintCell Biology