Maria Letizia Di Martino

This study establishes human apical-out ileal organoids as a model to study gut-nanomaterial interactions, showing charge-selective uptake regulated by the glycocalyx.

The paper screens gut metabolites for anti-infective activity against Salmonella and Shigella, identifying indole derivatives with structure-activity relationships affecting virulence and growth.

This study shows that maturation of human intestinal epithelial cells reduces susceptibility to Salmonella invasion by altering actin regulation, mucin expression, and glycocalyx composition.

The paper shows that the pcnB gene in Shigella flexneri promotes virulence by sustaining optimal levels of the virulence plasmid pINV, enhancing colonization and infection.

This study compares Salmonella and Shigella colonization strategies in human enteroids and colonoids, identifying distinct virulence factor modules that drive divergent infection kinetics and epithelial colonization patterns.

This study establishes and characterizes human jejunal enteroids for studying epithelial drug transport and metabolism, showing they recapitulate in vivo features and accurately predict drug pharmacokinetics.