Author

Jingxian Chen

Duke UniversityORCID 0000-0002-1642-6060Unclaimed ORCID profile · follow to get notified of new preprints

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Organism:C. elegans· 4 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

L. Ryan BaughiD· 4 shared Rojin Chitrakar· 4 shared Amy K. WebsteriD· 1 shared Angela L. WeiiD· 1 shared Erik C. AnderseniD· 1 shared Igor A. AntoshechkiniD· 1 shared Ivan B FalsztyniD· 1 shared James M. JordaniD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersGenetics

L. Ryan BaughORCID

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4 papers

Recent·Most cited

GenomicsbioRxivPreprintSep 9, 2026

An atlas of the C. elegans starvation response reveals that transcription is necessary to initiate transcriptional silencing in quiescent primordial germ cells

Jingxian Chen, Sharan Surya, Rojin Chitrakar…·L. Ryan Baugh

The paper creates a cellular atlas of gene expression in fed and starved C. elegans L1 larvae, revealing transcription in starved primordial germ cells and the role of aak-1/AMPK in chromatin compaction.

DOI 10.64898/2026.09.04.749554

C. elegansbulk RNA-seq

𝕏 PostBluesky

GeneticsLife Science AlliancePeer-reviewedApr 8, 2025

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance

Jingxian Chen, Rojin Chitrakar, L. Ryan Baugh

This study identifies DAF-18/PTEN's role in protecting LIN-35/Rb from cleavage by CLP-1/CAPN to enhance starvation resistance in C. elegans.

2 citations

C. elegansexperimental assay

𝕏 PostBluesky

GeneticsbioRxivPreprintFeb 28, 2025

Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental abnormalities in adult C. elegans

Ivan B Falsztyn, Jingxian Chen, Rojin Chitrakar…·L. Ryan Baugh

This paper identifies daf-18/PTEN and lin-35/Rb as tumor suppressors that counteract early life starvation-induced developmental abnormalities in C. elegans by modulating Hedgehog signaling and innate immunity.

DOI 10.1101/2025.02.28.640733

C. elegansDNA methylation

𝕏 PostBluesky

GeneticseLifePeer-reviewedJun 21, 2022

Natural variation in the irld gene family affects starvation resistance in C. elegans

Amy K. Webster, Rojin Chitrakar, Maya E. Powell…·L. Ryan Baugh

The paper identifies natural variation in the irld gene family affecting starvation resistance in C. elegans using MIP-seq and genome-wide association.

12 citations

C. elegansstatistical model

𝕏 PostBluesky