Author

Rojin Chitrakar

Duke University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 6 Developmental Biology· 2 Genomics· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 10 Approach:experimental assay· 7 Approach:statistical model· 5 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2

Frequent Co-Authors

L. Ryan BaughiD· 10 shared Amy K. WebsteriD· 5 shared Jingxian CheniD· 4 shared Erik C. AnderseniD· 2 shared Kinsey FisheriD· 2 shared Lewis StevensiD· 2 shared Robyn E. TannyiD· 2 shared Alan TraceyiD· 1 shared

Activity by Year

2018-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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10 shared papersGenetics

L. Ryan BaughORCID

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10 papers

Recent·Most cited

Large-scale pooled selection enables mapping of modifiers of RNAi gene knockdown effects in C. elegans

Stefan Zdraljevic, Alex Lee, Laura Walter-McNeill, Heriberto Marquez, Amy K. Webster, Rojin Chitrakar, Jameson Blount, L. Ryan Baugh, Joshua S. Bloom, Leonid Kruglyak

The paper develops a pooled selection platform to map modifiers of RNAi gene knockdown effects in C. elegans, identifying two classes of QTL influencing RNAi responses.

bioRxiv · Oct 11, 2026 · PreprintGenetics

An atlas of the C. elegans starvation response reveals that transcription is necessary to initiate transcriptional silencing in quiescent primordial germ cells

Jingxian Chen, Sharan Surya, Rojin Chitrakar, Jenna R. Valley, Marcos Francisco Perez, L. Ryan Baugh

The paper creates a cellular atlas of gene expression in fed and starved C. elegans L1 larvae, revealing transcription in starved primordial germ cells and the role of aak-1/AMPK in chromatin compaction.

bioRxiv · Sep 9, 2026 · PreprintGenomics

Nutrient-responsive and DAF-16/FoxO target H1 histone HIL-1 promotes resistance to starvation and bacterial pathogens in Caenorhabditis elegans

Kinsey Fisher, Rojin Chitrakar, L. Ryan Baugh

This study identifies HIL-1, a DAF-16/FoxO target gene, as a key mediator of starvation and bacterial pathogen resistance in C. elegans by activating immune-related genes during nutrient deprivation.

Genetics · Jun 15, 2026Peer-reviewedGenetics

DAF-18/PTEN protects LIN-35/Rb from CLP-1/CAPN-mediated cleavage to promote starvation resistance

Jingxian Chen, Rojin Chitrakar, L. Ryan Baugh

This study identifies DAF-18/PTEN's role in protecting LIN-35/Rb from cleavage by CLP-1/CAPN to enhance starvation resistance in C. elegans.

Life Science Alliance · Apr 8, 2025Peer-reviewedGenetics

Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental abnormalities in adult C. elegans

Ivan B Falsztyn, Jingxian Chen, Rojin Chitrakar, James M. Jordan, L. Ryan Baugh

This paper identifies daf-18/PTEN and lin-35/Rb as tumor suppressors that counteract early life starvation-induced developmental abnormalities in C. elegans by modulating Hedgehog signaling and innate immunity.

bioRxiv · Feb 28, 2025 · PreprintGenetics

Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest

Amy K. Webster, Rojin Chitrakar, Seth M. Taylor, L. Ryan Baugh

The paper shows that during starvation, somatic cells rely on active transcription for survival while germline cells use transcriptional quiescence and mRNA stability to preserve reproductive potential in C. elegans.

Cell Reports · Oct 1, 2022Peer-reviewedGenetics

Natural variation in the irld gene family affects starvation resistance in C. elegans

Amy K. Webster, Rojin Chitrakar, Maya E. Powell, Jingxian Chen, Kinsey Fisher, Robyn E. Tanny, Lewis Stevens, Kathryn S. Evans, Angela L. Wei, Igor A. Antoshechkin, Erik C. Andersen, L. Ryan Baugh

The paper identifies natural variation in the irld gene family affecting starvation resistance in C. elegans using MIP-seq and genome-wide association.

eLife · Jun 21, 2022Peer-reviewedGenetics

Chromosome-level reference genomes for two strains of Caenorhabditis briggsae: an improved platform for comparative genomics

Lewis Stevens, Nicolas D. Moya, Robyn E. Tanny, Sophia B Gibson, Alan Tracey, Huimin Na, Ye Zhan, Rojin Chitrakar, Job Dekker, Albertha J.M. Walhout, L. Ryan Baugh, Erik C. Andersen

The paper generates chromosome-level reference genomes for two C. briggsae strains, improving genomic resources for comparative genomics in the Caenorhabditis genus.

Genome Biology and Evolution · Mar 22, 2022Peer-reviewedGenomics

DAF-18/PTEN inhibits germline zygotic gene activation during primordial germ cell quiescence

Amanda L. Fry, Amy K. Webster, Julia Burnett, Rojin Chitrakar, L. Ryan Baugh, E. Jane Albert Hubbard

This study shows that DAF-18/PTEN maintains quiescence in primordial germ cells by inhibiting zygotic gene activation and cell division during starvation.

PLoS Genetics · Jul 21, 2021Peer-reviewedDevelopmental Biology

Perception of environmental polypeptides in C. elegans activates insulin/IGF signaling and alters lipid metabolism

Rebecca E. W. Kaplan, Amy K. Webster, Rojin Chitrakar, Joseph A. Dent, L. Ryan Baugh

The paper shows that food perception in C. elegans activates insulin/IGF signaling and alters lipid metabolism, but this response is harmful if feeding does not occur.

bioRxiv · Jun 7, 2018 · PreprintDevelopmental Biology