L. Ryan Baugh

The paper develops a pooled selection platform to map modifiers of RNAi gene knockdown effects in C. elegans, identifying two classes of QTL influencing RNAi responses.

The paper creates a cellular atlas of gene expression in fed and starved C. elegans L1 larvae, revealing transcription in starved primordial germ cells and the role of aak-1/AMPK in chromatin compaction.

This study identifies HIL-1, a DAF-16/FoxO target gene, as a key mediator of starvation and bacterial pathogen resistance in C. elegans by activating immune-related genes during nutrient deprivation.

This study identifies DAF-18/PTEN's role in protecting LIN-35/Rb from cleavage by CLP-1/CAPN to enhance starvation resistance in C. elegans.

This paper identifies daf-18/PTEN and lin-35/Rb as tumor suppressors that counteract early life starvation-induced developmental abnormalities in C. elegans by modulating Hedgehog signaling and innate immunity.

The paper assesses PFAS toxicity across genetically diverse C. elegans strains, finding genetic variation influences susceptibility to specific PFAS structures.

The paper shows that DAF-2/INSR ubiquitination by CHN-1/CHIP regulates IIS differently in larvae and adults, and under varying temperature and nutrient conditions.

The paper shows that during starvation, somatic cells rely on active transcription for survival while germline cells use transcriptional quiescence and mRNA stability to preserve reproductive potential in C. elegans.

The paper identifies natural variation in the irld gene family affecting starvation resistance in C. elegans using MIP-seq and genome-wide association.

The paper generates chromosome-level reference genomes for two C. briggsae strains, improving genomic resources for comparative genomics in the Caenorhabditis genus.

The paper investigates intergenerational stress adaptations in C. elegans across four stress types, finding conserved physiological responses with trade-offs, but no long-term transgenerational gene expression changes.

This study shows that DAF-18/PTEN maintains quiescence in primordial germ cells by inhibiting zygotic gene activation and cell division during starvation.

The paper investigates feedback regulation in the C. elegans insulin-like signaling network during state transitions, revealing widespread positive and negative feedback mechanisms.

This study investigates how maternal dietary restriction affects reproductive development in C. elegans by modulating insulin/IGF signaling, reducing starvation-induced abnormalities in progeny.

The paper shows that food perception in C. elegans activates insulin/IGF signaling and alters lipid metabolism, but this response is harmful if feeding does not occur.

The paper investigates how neurohormonal signalling via SSU-1 regulates insulin sensitivity and specificity in C. elegans under different environmental stresses.