Author

Annaka M. Saffron

Johns Hopkins UniversityORCID 0009-0002-4859-4082Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:experimental assay· 1

Frequent Co-Authors

Cosette A. RhoadsiD· 2 shared Duy Manh NguyeniD· 2 shared Elizabeth I. FlandreauiD· 2 shared Erin HernandeziD· 2 shared Huda AkiliD· 2 shared Jinglin XiongiD· 2 shared Megan Hastings HagenaueriD· 2 shared Stanley J. WatsoniD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Cosette A. RhoadsORCID

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3 papers

Recent·Most cited

Acute priming using elevated fluid viscosity recovers young-like single-cellsurveillance behaviors in aged human T cells

Yoseph W. Dance, Alice Amitrano, Annaka M. Saffron, Chanhong Min, Ladaisha T. Thompson, Zhuoxu Ge, Ian Michael Smith, Nicolas C. Macaluso, Charles Ezenwanne, Nicholas Milcik, Abigail Fennell, Kendall A. Pyndell, Kimberly M. Stroka, Jeremy D Walston, Sean X. Sun, , Jude M. Phillip

This study shows that increasing fluid viscosity can temporarily restore young-like surveillance behaviors in aged human T cells by improving deformability and sensing.

bioRxiv · Jan 14, 2026 · PreprintBioengineering

A Meta-Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence with Existing Human Data

Jinglin Xiong, Megan Hastings Hagenauer, Cosette A. Rhoads, Elizabeth I. Flandreau, Nancy Rempel-Clower, Erin Hernandez, Duy Manh Nguyen, Annaka M. Saffron, Toni Q. Duan, Stanley J. Watson, Huda Akil

This paper identifies 133 consistently differentially expressed genes in the prefrontal cortex of chronically stressed mice across multiple stress paradigms and finds convergence with human psychiatric disorder gene expression patterns.

Brain and Behavior · Jan 1, 2026Peer-reviewedNeuroscience

A Meta-Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models

Cosette A. Rhoads, Megan Hastings Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka M. Saffron, Elizabeth I. Flandreau, Stanley J. Watson, Huda Akil

This study performs a meta-analysis of rodent sleep deprivation transcriptome data to identify consistently differentially expressed genes across multiple studies.

Journal of Sleep Research · Oct 1, 2025Peer-reviewedNeuroscience