Author

Ruby A. Sims

University of California, Los AngelesORCID 0000-0002-1667-2771Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Beate IllekiD· 1 shared Brigitte N. GompertsiD· 1 shared Colin J. JuettiD· 1 shared Donald B. KohniD· 1 shared Emily C. DugganiD· 1 shared Joseph D. Long· 1 shared Lindsay E. LathropiD· 1 shared Neil Fernandes· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperGenetics

Beate IllekORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Investigation of Double-Stranded DNA Donors and CRISPR-Cas9 RNP for Universal Correction of Mutations Causing Cystic Fibrosis in Human Airway Cells

Vrishti Sinha, Paul George Ayoub, Colin J. Juett, Lindsay E. Lathrop, Ruth A. Foley, Ruby A. Sims, Joseph D. Long, Emily C. Duggan, Neil Fernandes, Beate Illek, Brigitte N. Gomperts, Steven John Jonas, Donald B. Kohn

This study demonstrates that low levels of CFTR integration can restore chloride ion currents in human airway cells using optimized nonviral CRISPR-Cas9 RNP and double-stranded DNA donors.

bioRxiv · Sep 21, 2025 · PreprintGenetics