Thomas Van Brussel

Functional Deorphanization of Tumor-reactive TCRs Uncovers a Landscape of Shared, Immune Dominant Antigens across Cancers

This study introduces TWISTAR, a platform to identify tumor-reactive TCRs and their antigens, revealing shared immunogenic targets across cancers and immune dominance.

Intermediate molecular phenotypes to identify genetic markers of anthracycline-induced cardiotoxicity risk

The paper identifies genetic markers for anthracycline-induced cardiotoxicity risk by analyzing intermediate molecular phenotypes in mice and human cohorts.

Discriminating Mild from Critical COVID-19 by Innate and Adaptive Immune Single-cell Profiling of Bronchoalveolar Lavages

This study uses single-cell profiling of bronchoalveolar lavages to compare immune responses in mild and critical COVID-19, identifying differences in T-cell function and macrophage differentiation that correlate with disease severity.