Author

Jieyi Xiong

VIB-KU Leuven Center for Cancer BiologyORCID 0000-0002-4302-3515Unclaimed ORCID profile · follow to get notified of new preprints

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Jieyi Xiong1 paper

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Diether LambrechtsiD· 2 shared Alf HamanniD· 1 shared Ann SmeetsiD· 1 shared Anupam N. SinhaiD· 1 shared Azim Dehghani Amirabad· 1 shared Barbara HutteriD· 1 shared Bärbel Felder· 1 shared Benedikt BrorsiD· 1 shared

Activity by Year

2016-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

Diether LambrechtsORCID

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3 papers

Recent·Most cited

Functional Deorphanization of Tumor-reactive TCRs Uncovers a Landscape of Shared, Immune Dominant Antigens across Cancers

Orian Bricard, Razgar Seyed Rahmani, Frederik Peeters, Chloe Lorent, Thomas Van Brussel, Jieyi Xiong, Evy Vanderheyden, Rogier Schepers, Gino Philips, Eva Lion, Jiska van der Reest, Georg A. Halder, Ann Smeets, Michael Platten, Edward W. Green, , Diether Lambrechts

This study introduces TWISTAR, a platform to identify tumor-reactive TCRs and their antigens, revealing shared immunogenic targets across cancers and immune dominance.

bioRxiv · Oct 5, 2026 · PreprintCancer Biology

DNA Methylation Repels Binding of HIF Transcription Factors to Maintain Tumour Immunotolerance

Flora D’Anna, Laurien Van Dyck, Jieyi Xiong, Hui Zhao, Rebecca V. Berrens, Junbin Qian, Paweł Bieniasz-Krzywiec, Vikas Chandra, Luc Schoonjans, Jason B. Matthews, Julie De Smedt, Liesbeth Minnoye, Ricardo Amorim, Sepideh Khorasanizadeh, Qian Yu, , Diether Lambrechts

The paper shows DNA methylation prevents HIF binding, affecting hypoxia responses and tumour immunotolerance.

Genome biology · Jul 27, 2020Peer-reviewedGenomics

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction

Florian Schmidt, Nina Gasparoni, Gilles Gasparoni, Kathrin Gianmoena, Cristina Cadenas, Julia K. Polansky, Peter Ebert, Karl J. V. Nordström, Matthias Barann, Anupam N. Sinha, Sebastian Fröhler, Jieyi Xiong, Azim Dehghani Amirabad, Fatemeh Behjati Ardakani, Barbara Hutter, , Marcel H. Schulz

This paper introduces TEPIC, a method that combines open-chromatin data with TF binding affinities to predict gene expression, achieving results comparable to TF ChIP-seq.

Nucleic Acids Research · Oct 24, 2016Peer-reviewedBioinformatics