Michael Platten

This study introduces TWISTAR, a platform to identify tumor-reactive TCRs and their antigens, revealing shared immunogenic targets across cancers and immune dominance.

The paper identifies CD4+ tissue-resident memory T-cells as markers of response to immune checkpoint inhibition in high-grade glioma.

This paper develops a method to generate tumor-specific neoantigens using RNA editing, demonstrating its ability to create immunogenic epitopes that activate T cells and enhance immunotherapy potential.

The paper shows that irradiation reprograms tumor endothelium to enhance T cell infiltration and effector function in gliomas, improving immunotherapy outcomes.

This paper introduces an automated image-based cell sorting method that enriches activated T cells from blood with high throughput and label-free morphology-based classification.

HIV-1 suppresses Th1 polarization by disrupting CD4 T cell-Dendritic cell communication through Nef-mediated CD4 downregulation.

This study identifies rare tumor-reactive T cells and conserved antigen repertoires in multiple myeloma and acute myeloid leukemia, developing a TCR fitness model to predict immunotherapy response.

makeTCR provides a modular platform for rapid, scalable, single-step TCR synthesis and validation, enabling functional testing within 48 hours.

This study shows DJ-1 affects metabolism and immune response differently in Parkinson's disease and glioblastoma cells, with antioxidant treatment rescuing PD-related phenotypes.

The paper introduces optiPRM, a targeted LC-MS workflow that enhances sensitivity for detecting mutation-derived neoepitopes from limited tumor samples.

T-FINDER identifies T cell epitopes and their cognate receptors by analyzing HLA-presented peptides, demonstrating its utility in multiple diseases.

This study describes a patient with diffuse midline glioma who achieved remission after vaccination with an H3K27M peptide vaccine, showing robust T and B cell responses across diverse HLA alleles.

This study shows that MHC class II antigen presentation on blood-borne myeloids is essential to maintain functional CD8+ T cells in brain tumors by preventing Tox-driven dysfunction.

This study shows that targeting scavenger receptors Stabilin-1 and Stabilin-2 reduces atherosclerosis by altering the plasma proteome, which suppresses monocyte/macrophage activity.

This paper introduces moleculaR, a computational framework for probabilistic mapping and statistical testing of metabolites in mass spectrometry imaging data.

This study integrates phospho-proteogenomic and single-cell transcriptomic data to subtype meningiomas and identify subtype-specific immune infiltration patterns.

This study develops a glioblastoma cell line from a genetic mouse model that mimics human glioblastoma features, enabling preclinical testing of immunotherapies.