Author

Isabelle Léna

Centre National de la Recherche ScientifiqueORCID 0000-0002-1708-8497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

Massimo MantegazzaiD· 3 shared Lara PizzamiglioiD· 2 shared Alexandre Loucif· 1 shared Elisabetta MennaiD· 1 shared Evgeniia Rusina· 1 shared Fabrice DupratiD· 1 shared Fabrizio CapitanoiD· 1 shared Flavia AntonucciiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Massimo MantegazzaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeuroscienceGenes Brain & BehaviorPeer-reviewedAug 31, 2025

Sex-specific behavioral features of juvenile and adult haploinsufficient Scn2a+/- female mice, model of Autism Spectrum Disorder

Wendy Marcantonio, Martina Simonti, Isabelle Léna, Massimo Mantegazza

This study investigates sex-specific behavioral features in Scn2a+/- mice, showing females exhibit milder ASD-like traits compared to males, with differences in sociability, risk-taking, and reactivity.

8 citationstop 4%

mouseexperimental assay

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NeuroscienceNeurobiology of DiseasePeer-reviewedFeb 26, 2025

Neurodevelopmental defects in Dravet syndrome Scn1a+/- mice: targeting GABA-switch rescues behavioral dysfunctions but not seizures and mortality.

Lara Pizzamiglio, Fabrizio Capitano, Evgeniia Rusina…·Massimo Mantegazza

10 citationstop 3%

mouseexperimental assay

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NeuroscienceJournal of Clinical InvestigationPeer-reviewedSep 7, 2021

GABAergic neurons and Nav1.1 channel hyperactivity: a novel neocortex-specific mechanism of cortical spreading depression.

Oana Chever, Sarah Zerimech, Paolo Scalmani…·Massimo Mantegazza

This study identifies a neocortex-specific mechanism of cortical spreading depression (CSD) initiated by hyperactivity of GABAergic neurons and NaV1.1 channel gain-of-function, linking it to Familial Hemiplegic Migraine type-3.

55 citationstop 3%

humanelectronic health records

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