Francesco Bonollo

The paper uses spatial single-cell proteomics to map multicellular niches in primary prostate cancer, identifying prognostic cell types and niches beyond Gleason grading.

This study identifies iron metabolism as a therapeutic target in stem cell-like castration-resistant prostate cancer by showing that inhibiting NRF2 induces ferroptosis in CD44hi cells.

This study identifies the YAP1-TGFβ1 axis as a driver of androgen receptor loss in prostate cancer-associated fibroblasts, showing its role in promoting aggressive disease and resistance to therapy.

This paper introduces VirtualMultiplexer, a generative AI tool that translates H&E images to IHC images, improving clinical predictions and accelerating histopathology workflows.

This paper shows DHX30 coordinates cytoplasmic and mitochondrial translation, affecting cancer cell survival and prognosis through a 15-gene signature.