Author

Joseph Liang

University of British ColumbiaORCID 0000-0002-0630-2769Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:imaging· 2 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Catharine H. RankiniD· 4 shared Kota MizumotoiD· 2 shared Troy A. McDiarmidiD· 2 shared Aaron D. LoeweniD· 1 shared Alvaro Luna Cortes· 1 shared Anushka Sood· 1 shared Ardalan HendiiD· 1 shared Dawson Born· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersNeuroscience

Catharine H. RankinORCID

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4 papers

Recent·Most cited

The Challenge of Choosing a Negative Control: A Behavioural and Morphological Characterization of Various unc-43 LOF Alleles in the Model Organism C. elegans

Joseph Liang, Anushka Sood, Gayatree Khanna, Catharine H. Rankin

The paper evaluates phenotypic variation among unc-43 LOF alleles in C. elegans to identify reliable reference alleles for future studies.

bioRxiv · Jun 26, 2025 · PreprintGenetics

A Familial Alzheimers Disease Associated Mutation in Presenilin-1 Mediates Amyloid-Beta Independent Cell Specific Neurodegeneration

Mahraz Parvand, Joseph Liang, Tahereh Bozorgmehr, Dawson Born, Alvaro Luna Cortes, Catharine H. Rankin

This study shows that a familial Alzheimer's disease mutation in presenilin-1 causes cell-specific neurodegeneration in C. elegans independent of amyloid-beta, which is rescued by over-expression of wild-type human presenilin.

PLoS ONE · Sep 6, 2024Peer-reviewedNeuroscience

Systematic phenomics analysis of ASD-associated genes reveals shared functions and parallel networks underlying reversible impairments in habituation learning

Troy A. McDiarmid, Manuel Belmadani, Joseph Liang, Fabian Meili, Eleanor Mathews, Gregory P. Mullen, Ardalan Hendi, Wan-Rong Wong, James B. Rand, Kota Mizumoto, Kurt Z. Haas, Paul Pavlidis, Catharine H. Rankin

This study systematically analyzes ASD-associated genes in C. elegans, identifying phenotypic relationships and reversible impairments in habituation learning.

Proceedings of the National Academy of Sciences · Nov 21, 2019Peer-reviewedNeuroscience

CRISPR-Cas9 human gene replacement and phenomic characterization in Caenorhabditis elegans to understand the functional conservation of human genes and decipher variants of uncertain significance

Troy A. McDiarmid, Vinci Au, Aaron D. Loewen, Joseph Liang, Kota Mizumoto, Donald G. Moerman, Catharine H. Rankin

This paper uses CRISPR-Cas9 in C. elegans to replace human genes and assess their function, showing it can classify disease variants accurately.

Disease Models & Mechanisms · Jan 1, 2018Peer-reviewedMolecular Biology