Matthew T. Schmitz

The paper describes the iterative creation of harmonized ontologies and 3D frameworks for the basal ganglia across human and non-human primates to enable cross-species comparisons of cellular and molecular data.

The paper presents a high-accuracy T2T rhesus macaque genome assembly, identifies subtelomeric repeats as a challenge, and reveals new genomic features and functional elements in these regions.

The paper maps conserved cell type signatures in the adult mouse brainstem and spinal cord using multi-omics data, revealing shared and region-specific features.

CellBouncer demultiplexes and analyzes pooled single-cell data, revealing mitochondrial incompatibilities between humans and chimpanzees.

The paper develops a cross-species enhancer-AAV toolkit for targeting specific cell types in the basal ganglia across species, validated in mouse and macaque.

The paper creates a cross-species spinal cord cell type atlas integrating data from mouse, macaque, and human, identifying conserved and species-specific features.

The paper examines HCN-channel properties in primate supragranular pyramidal neurons, finding conserved traits across species with some divergence in magnitude between humans and macaques.

The paper defines major axes of human basal ganglia astrocyte specialization using a multimodal atlas and identifies enhancer code for targeted viral tools.

The paper creates a cross-species consensus atlas of primate basal ganglia cell types using multiomic data from human, macaque, and marmoset, identifying 61 conserved cell types and a novel hybrid medium spiny neuron type.

The paper analyzes the conservation and evolution of striatal interneurons across mammals, finding that TAC3 interneurons are conserved and that neuronal types evolve through redistribution and refinement.

ANTIPODE integrates single-cell data across species to identify homologous cell types and reveal gene regulatory divergence in developing mammalian brains.

This study shows that the identity of MGE-derived cortical interneurons can be dynamically influenced by their environment, with human 3D models promoting Pvalb expression over Sst.

This study shows that co-differentiating human and mouse pluripotent stem cells accelerates human neural differentiation, with gene expression changes correlating with in utero development.