Author

Jennifer L. Chlebek

Lawrence Livermore National LaboratoryORCID 0000-0002-1744-0016Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Biophysics· 1 Microbiology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:bacteria (other)· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Dante P. RicciiD· 3 shared Christina S. Kang-YuniD· 2 shared Dan M. ParkiD· 2 shared Sean P. LeonardiD· 2 shared Yongqin JiaoiD· 2 shared Adam N. Laurence· 1 shared Ankur B. DaliaiD· 1 shared Chao LiuiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

Dante P. RicciORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The stoichiometry of minor-to-major pilins regulates the dynamic activity of the type IVa competence pilus in Vibrio cholerae

Nicholas D. Christman, Triana N. Dalia, Jennifer L. Chlebek, Ankur B. Dalia

This study shows that the ratio of minor-to-major pilins regulates the dynamic activity of T4aP in Vibrio cholerae.

PLoS Genetics · Jun 4, 2026Peer-reviewedMicrobiology

Rapid Antibody Fragment Production and Binding Analysis Using Cell-Free Protein Synthesis Combined with Fluorescence Correlation Spectroscopy

Shakiba Nikfarjam, Chao Liu, Emma J. Laurence, Adam N. Laurence, Jennifer L. Chlebek, Dante P. Ricci, Steven A. Hoang-Phou, Ted A. Laurence, Matthew A. Coleman

This paper develops a cell-free protein synthesis method combined with FCS to rapidly produce and characterize antibody fragments, showing improved solubility and binding analysis.

bioRxiv · Aug 5, 2025 · PreprintBiophysics

GENTANGLE: integrated computational design of gene entanglements

Jose Manuel Martí, Chloe Hsu, Charlotte Rochereau, Chenling A. Xu, Tomasz Blazejewski, Hunter M. Nisonoff, Sean P. Leonard, Christina S. Kang-Yun, Jennifer L. Chlebek, Dante P. Ricci, Dan M. Park, Harris H. Wang, Jennifer Listgarten, Yongqin Jiao, Jonathan Allen

GENTANGLE is a computational tool for designing overlapping gene pairs in microbial genomes, enabling safer genetic engineering through gene entanglements.

Bioinformatics · Jun 21, 2024Peer-reviewedBioinformatics

Prolonging Genetic Circuit Stability through Adaptive Evolution of Overlapping Genes

Jennifer L. Chlebek, Sean P. Leonard, Christina S. Kang-Yun, Mimi C. Yung, Dante P. Ricci, Yongqin Jiao, Dan M. Park

This paper demonstrates how sequence entanglement and adaptive evolution can stabilize synthetic genetic circuits by altering mutational landscapes and reducing circuit burden.

Nucleic Acids Research · May 24, 2023Peer-reviewedSynthetic Biology