Author

Trung Viet Nguyen

Harry Perkins Institute of Medical ResearchORCID 0000-0002-1749-8509Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Christian PfluegeriD· 2 shared Jahnvi PfluegeriD· 2 shared Ryan ListeriD· 2 shared Tessa SwainiD· 2 shared Christian Maximilian NefzgeriD· 1 shared Daniel PoppeiD· 1 shared Dennis Eng Kiat TaniD· 1 shared Ethan FordiD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersSynthetic Biology

Christian PfluegerORCID

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2 papers

Recent·Most cited

Synthetic BiologyNucleic Acids ResearchPeer-reviewedNov 2, 2023

A modular dCas9-based recruitment platform for combinatorial epigenome editing

Tessa Swain, Christian Pflueger, Saskia Freytag…·Ryan Lister

The paper introduces a modular dCas9-based platform for combinatorial epigenome editing, demonstrating its ability to control effector recruitment and spatial organization for improved transcriptional regulation.

35 citations

CRISPR screenexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivFeb 15, 2018

A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs

Christian Pflueger, Dennis Eng Kiat Tan, Tessa Swain…·Ryan Lister

This paper develops a modular dCas9-SunTag DNMT3A system to improve DNA methylation editing specificity and reduce off-target effects compared to direct fusion constructs.

188 citations

humanDNA methylation

𝕏 PostBluesky