Jahnvi Pflueger

The paper identifies and characterizes DNA methylation reader proteins in Arabidopsis thaliana, revealing context-specific binding preferences and functional roles.

The paper introduces a modular dCas9-based platform for combinatorial epigenome editing, demonstrating its ability to control effector recruitment and spatial organization for improved transcriptional regulation.

The paper examines DNA methylation patterns in neurons derived from mouse ES-cells and cultured primary neurons, finding similarities and differences in mCH deposition compared to in vivo conditions.

This paper develops CRISPRi-based gene circuits in Arabidopsis for implementing logic gates and modular control of gene expression.

The paper introduces synthetic gene circuits in plants that enable programmable reconfiguration of transcriptional activity through logic gates and genetic recombination.

This study identifies that amyloid plaque phagocytosis through Hif1α controls microglial phenotypes in Alzheimer’s disease in both mice and humans.

This paper creates a single-cell brain atlas of Alzheimer’s disease, identifying cell-type specific gene expression patterns and regulatory networks associated with disease.

This paper develops a modular dCas9-SunTag DNMT3A system to improve DNA methylation editing specificity and reduce off-target effects compared to direct fusion constructs.