Author

Ethan Ford

The University of Western AustraliaORCID 0000-0002-8563-199XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:DNA methylation· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Organism:mouse· 1

Frequent Co-Authors

Ryan ListeriD· 3 shared Christian Maximilian NefzgeriD· 2 shared Jose Maria PoloiD· 2 shared Alex de MendozaiD· 1 shared Anja S. KnauppiD· 1 shared Cheng HuangiD· 1 shared Christian PfluegeriD· 1 shared Dennis Eng Kiat TaniD· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenomics

Ryan ListerORCID

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3 papers

Recent·Most cited

TINC - a method to dissect transcriptional complexes at single locus resolution - reveals novel Nanog regulators in mouse embryonic stem cells

Anja S. Knaupp, Monika Mohenska, Michael R. Larcombe, Ethan Ford, SM Lim, Ka Wai Wong, Jinxin Chen, Jaber Firas, Cheng Huang, Xiangqiong Liu, Thu Anh Nguyen, YBY Sun, M L Holmes, P Tripathi, Fernando Jaime Rossello, , Jose Maria Polo

bioRxiv · Apr 3, 2020 · PreprintGenomics

A modular dCas9-SunTag DNMT3A epigenome editing system overcomes pervasive off-target activity of direct fusion dCas9-DNMT3A constructs

Christian Pflueger, Dennis Eng Kiat Tan, Tessa Swain, Trung Viet Nguyen, Jahnvi Pflueger, Christian Maximilian Nefzger, Jose Maria Polo, Ethan Ford, Ryan Lister

This paper develops a modular dCas9-SunTag DNMT3A system to improve DNA methylation editing specificity and reduce off-target effects compared to direct fusion constructs.

bioRxiv · Feb 15, 2018Molecular Biology

Frequent lack of repressive capacity of promoter DNA methylation identified through genome-wide epigenomic manipulation

Ethan Ford, Matthew Grimmer, Sabine Stolzenburg, Ozren Bogdanović, Alex de Mendoza, Peggy Farnham, Pilar Blancafort, Ryan Lister

Forcing DNA methylation onto thousands of human promoters with a zinc finger-DNMT3A fusion often fails to repress them, and the mark is quickly erased at H3K4me3-marked promoters.

bioRxiv · Sep 20, 2017 · PreprintGenomics