Xiaomeng Jia

The paper investigates signal anisotropy in pump-probe microscopy by analyzing how detection angles affect signal components and amplitude, revealing directional dependence from nonlinear processes.

This study shows that chromatin buffers torsional stress during transcription by enabling Pol II to transcribe through nucleosomes more efficiently than on single-nucleosome substrates.

This study develops a high-resolution assay to show that the replisome, composed of helicase and DNA polymerase, is a powerful torsional motor that regulates DNA replication stalling and reactivation.

This study investigates how DNA polymerase interacts with the replication fork under stress and finds that prolonged stress inactivates replication and locks the fork, which is reversible only by helicase.