Author

David M. Shostak

Gladstone InstitutesORCID 0000-0002-1768-6374Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Claire Ellis· 3 shared Jeremy Nguyen· 3 shared Jessica R. BlumenfeldiD· 3 shared Kaylie Suan· 3 shared Leon Yao· 3 shared Min Joo KimiD· 3 shared Oscar YipiD· 3 shared Samuel De Leon· 3 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Claire Ellis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NeurosciencebioRxivPreprintDec 13, 2025

Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model

Oscar Yip, Leon Yao, Jessica R. Blumenfeld…·Yadong Huang

DOI 10.64898/2025.12.10.693468

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 9, 2025

Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease

Min Joo Kim, Jessica R. Blumenfeld, Yaqiao Li…·Yadong Huang

This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 25, 2025

Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer's disease mouse model

Jessica R. Blumenfeld, Yaqiao Li, Min Joo Kim…·Yadong Huang

This study shows neuronal APOE4 alone can drive tau pathology, neurodegeneration, and neuroinflammation in a mouse model, similar to a human APOE4 knock-in model.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky