Author
Gladstone InstitutesORCID 0000-0001-9096-7167Unclaimed ORCID profile · follow to get notified of new preprints
6 papers
Recent·Most cited
Dennis R. Tabuena, Sung-Soo Jang, Brian P. Grone…·Misha Y. Zilberter
This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.
Min Joo Kim, Jessica R. Blumenfeld, Yaqiao Li…·Yadong Huang
This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.
Jessica R. Blumenfeld, Yaqiao Li, Min Joo Kim…·Yadong Huang
This study shows neuronal APOE4 alone can drive tau pathology, neurodegeneration, and neuroinflammation in a mouse model, similar to a human APOE4 knock-in model.
Antara T. Rao, Nuo Chen, Min Joo Kim…·Yadong Huang
The paper investigates the role of microglia in APOE4-driven Alzheimer's pathology using a chimeric model, finding that microglia are required for APOE4-induced pathologies.
Michael Seamus Haney, Róbert Pálovics, Christy Nicole Munson…·Tony Wyss‐Coray
The paper links APOE4/4 genotype to lipid droplet accumulation in Alzheimer's microglia, showing its role in neurotoxicity through triglyceride synthesis and Tau phosphorylation.