Jessica R. Blumenfeld

Neuronal APOE4-induced Early Hippocampal Network Hyperexcitability in Alzheimers Disease Pathogenesis

This study identifies early hippocampal network hyperexcitability in APOE4 mice, linked to Nell2 overexpression, and shows its role in AD pathogenesis.

Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model

Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease

This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.

Tri-AD: Hippocampal cell-type-specific responses to age, sex and APOE genotype

The paper investigates how age, sex, and APOE genotype affect hippocampal cell-type-specific gene expression and communication in mice, revealing sex-divergent effects of APOE4.

Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer's disease mouse model

This study shows neuronal APOE4 alone can drive tau pathology, neurodegeneration, and neuroinflammation in a mouse model, similar to a human APOE4 knock-in model.

Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease

The paper identifies a cell-type-directed combination therapy for Alzheimer's disease using single-cell transcriptomics and drug databases, showing improved memory and reduced pathologies in a mouse model.

Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model

The paper investigates the role of microglia in APOE4-driven Alzheimer's pathology using a chimeric model, finding that microglia are required for APOE4-induced pathologies.