Yaqiao Li

Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea

This study delivers GJB2 specifically to target cells in mouse models of DFNB1 deafness, restoring hearing function and validating the approach in nonhuman primates.

Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease

This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

This study shows that CT-KIBRA repairs synaptic plasticity and memory in tauopathy models by stabilizing PKMζ, without altering tau levels or preventing synapse loss.

PCDH15 Dual-AAV Gene Therapy for Deafness and Blindness in Usher Syndrome Type 1F

This paper demonstrates a dual-AAV gene therapy strategy for USH1F, restoring hearing, balance, and retinal function in mouse and human models.

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

This study shows that microglial NF-κB signaling drives tau spreading and toxicity in a mouse model of tauopathy, with inhibition reducing tau pathology and cognitive deficits.

A Mac2-positive progenitor-like microglial population survives independent of CSF1R signaling in adult mouse brain

The paper identifies a Csf1r-independent microglial subset in adult mice that exhibits progenitor-like features and is distinct from homeostatic microglia.

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

Tau Secretion and Propagation Is Regulated by p300/CBP via Autophagy-Lysosomal Pathway in Tauopathy

This study identifies p300/CBP as a regulator of tau secretion via the autophagy-lysosomal pathway, showing its role in tau propagation in tauopathies.

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

This study shows that adult microglia self-renew to restore homeostasis after ablation, with specific maturation programs and spatial organization.