Author

Leon Yao

Gladstone Institutes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Claire Ellis· 3 shared David M. ShostakiD· 3 shared Jeremy Nguyen· 3 shared Jessica R. BlumenfeldiD· 3 shared Kaylie Suan· 3 shared Min Joo KimiD· 3 shared Oscar YipiD· 3 shared Samuel De Leon· 3 shared

Activity by Year

2025-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Claire Ellis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Neuronal APOE4 reduction with an APOE-I3-targeting ASO protects against neurodegeneration and neuroinflammation in an Alzheimer's disease mouse model

Oscar Yip, Leon Yao, Jessica R. Blumenfeld, Min Joo Kim, David M. Shostak, Zoe Platow, Kaylie Suan, Yaqiao Li, Claire Ellis, Alice An, Yanxia Hao, Qin Xu, Samuel De Leon, Jeremy Nguyen, Yadong Huang

bioRxiv · Dec 13, 2025 · PreprintNeuroscience

Neuronal APOE4 drives damaging lipid accumulation via contact-dependent neuron-oligodendrocyte-microglia interaction in Alzheimer's disease

Min Joo Kim, Jessica R. Blumenfeld, Yaqiao Li, Oscar Yip, Leon Yao, Stephanie Ancheta, Samuel De Leon, Zoe Platow, Zherui Liang, David M. Shostak, Kaylie Suan, Yanxia Hao, Nicole Koutsodendris, Claire Ellis, Jeremy Nguyen, Yadong Huang

This study shows neuronal APOE4 drives lipid accumulation in AD through neuron-oligodendrocyte-microglia interactions, with microglia showing preferential lipid buildup.

bioRxiv · Dec 9, 2025 · PreprintNeuroscience

Neuronal APOE4 alone is sufficient to drive tau pathology, neurodegeneration, and neuroinflammation in an Alzheimer's disease mouse model

Jessica R. Blumenfeld, Yaqiao Li, Min Joo Kim, Oscar Yip, Leon Yao, Samuel De Leon, Rebecca Fulthorpe, David M. Shostak, Zoe Platow, Kaylie Suan, Yanxia Hao, Nicole Koutsodendris, Claire Ellis, Jeremy Nguyen, Yadong Huang

This study shows neuronal APOE4 alone can drive tau pathology, neurodegeneration, and neuroinflammation in a mouse model, similar to a human APOE4 knock-in model.

bioRxiv · Nov 25, 2025 · PreprintNeuroscience