Sara N. Burke

This study develops a touchscreen-based morph discrimination task for rats and finds no age-related mnemonic similarity deficits, contrasting previous 3D object-based findings.

This study examines how different diets affect metabolism-related gene expression in aged rats' tissues and links these changes to cognitive performance.

This study examines the effects of a ketogenic diet on neural activity in the prelimbic cortex and CA3 of young and aged rats, finding increased activation in the PL but no change in CA3.

MetaVision3D converts serial 2D MALDI mass spectrometry imaging sections into a 3D spatial metabolome atlas using computer vision techniques.

The paper presents a method for simultaneous spatial analysis of metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging and a computational framework called Sami.

This study examines if perforant path fiber loss affects Arc expression in CA3 and LEC, finding no change in Arc expression despite impaired task performance.

The paper examines how the power spectrum of hippocampal LFP degrades during euthanasia, finding that the 1/f slope is maintained until energy is fully quenched, supporting an energy cascade theory.

This study shows that prefrontal cortex inactivation impairs mnemonic discrimination in a similarity task regardless of lure novelty, unlike hippocampal inactivation.

The paper examines age-related changes in Arc expression in prelimbic cortical neurons during behavior, finding reduced expression linked to multitasking deficits, with no projection neuron specificity in the prelimbic cortex unlike the perirhinal cortex.

This study shows that time-restricted feeding improves biconditional associative learning in aged rats, regardless of diet type, suggesting potential benefits for cognitive health.

This study examines sex and age differences in cognitive and physical performance in rats, finding age-related declines in both sexes but no significant sex differences in cognitive tasks.

This study uses multi-scale imaging to show that aged rats have altered functional connectivity and increased dorsal striatal Arc expression during cognitive multi-tasking.

This study examines how aging and a ketogenic diet affect synapse-related gene expression in different hippocampal subregions, showing subregion-specific changes.

The paper investigates the relationship between slow gamma and theta harmonics in hippocampal LFPs, finding that slow gamma is not a distinct oscillation but an artifact of decomposition methods.

This study investigates how muscimol-induced hippocampal excitation affects mnemonic discrimination in rats, finding that it impairs performance on novel stimuli but not familiar ones.

The paper examines how theta and gamma oscillations in hippocampal LFPs correlate with running speed, finding increased amplitude-amplitude and phase-amplitude coupling at higher velocities.

The paper proposes a nonlinear dynamical model based on the three-wave equation to analyze cross-frequency coupling in hippocampal LFPs, showing unambiguous theta-gamma coupling.

This study shows that a ketogenic diet reduces adiposity and reverses age-related declines in hippocampal transporter expression in aged rats.