Author

Xin Yi Choo

The University of MelbourneORCID 0000-0002-1783-0102Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Alexandra GrubmaniD· 2 shared Catriona McLeaniD· 2 shared Dulce B. Vargas-LandíniD· 2 shared Enrico G. PetrettoiD· 2 shared Gabriel ChewiD· 2 shared Guizhi Sun· 2 shared Jahnvi PfluegeriD· 2 shared John F. OuyangiD· 2 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Alexandra GrubmanORCID

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2 papers

Recent·Most cited

Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1α

Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Guizhi Sun, Nathan P. Croft, Fernando Jaime Rossello, Rebecca K. Simmons, Sam Buckberry, Dulce B. Vargas-Landín, Jahnvi Pflueger, Teresa H. Vandekolk, Zehra C. Abay, Xiaodong Liu, John M. Haynes, , Jose Maria Polo

This study identifies that amyloid plaque phagocytosis through Hif1α controls microglial phenotypes in Alzheimer’s disease in both mice and humans.

bioRxiv · May 17, 2019 · PreprintNeuroscience

A single cell brain atlas in human Alzheimer’s disease

Alexandra Grubman, Gabriel Chew, John F. Ouyang, Guizhi Sun, Xin Yi Choo, Catriona McLean, Rebecca K. Simmons, Sam Buckberry, Dulce B. Vargas-Landín, Jahnvi Pflueger, Ryan Lister, Owen J. L. Rackham, Enrico G. Petretto, Jose Maria Polo

This paper creates a single-cell brain atlas of Alzheimer’s disease, identifying cell-type specific gene expression patterns and regulatory networks associated with disease.

bioRxiv · May 14, 2019 · PreprintNeuroscience