Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1α
Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Guizhi Sun, Nathan P. Croft, Fernando Jaime Rossello, Rebecca K. Simmons, Sam Buckberry, Dulce B. Vargas-Landín, Jahnvi Pflueger, Teresa H. Vandekolk, Zehra C. Abay, Xiaodong Liu, John M. Haynes, , Jose Maria Polo
This study identifies that amyloid plaque phagocytosis through Hif1α controls microglial phenotypes in Alzheimer’s disease in both mice and humans.
bioRxiv · May 17, 2019 · PreprintNeuroscience