Dulce B. Vargas-Landín

Single-cell analysis reveals cellular heterogeneity and limits of marker-based assessment in retinal ganglion cell-enriched organoid cultures

The paper uses single-cell RNA sequencing to characterize cellular heterogeneity in RGC-enriched retinal organoids and shows marker-based assessments may overestimate RGC identity.

Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1α

This study identifies that amyloid plaque phagocytosis through Hif1α controls microglial phenotypes in Alzheimer’s disease in both mice and humans.

A single cell brain atlas in human Alzheimer’s disease

This paper creates a single-cell brain atlas of Alzheimer’s disease, identifying cell-type specific gene expression patterns and regulatory networks associated with disease.