Rebecca K. Simmons

The paper examines DNA methylation patterns in neurons derived from mouse ES-cells and cultured primary neurons, finding similarities and differences in mCH deposition compared to in vivo conditions.

This study evaluates deconvolution methods for human brain transcriptome data, finding that cell-type signatures impact accuracy more than methods, and partial methods outperform complete ones.

The paper compares single-cell and single-nucleus RNA-seq workflows in adult mouse kidneys to identify protocol-specific biases in cell type recovery and transcriptional profiles.

This study identifies that amyloid plaque phagocytosis through Hif1α controls microglial phenotypes in Alzheimer’s disease in both mice and humans.

This paper creates a single-cell brain atlas of Alzheimer’s disease, identifying cell-type specific gene expression patterns and regulatory networks associated with disease.