Jishizhan Chen

This study develops a cross-species framework linking collagen structure to mechanical vulnerability in intervertebral discs using multiscale imaging and modeling.

This paper uses HiP-CT to image the human spine at high resolution, revealing multiscale anatomy and microstructural features without exogenous contrast.

This study shows that microarchitectural features of articular calcified cartilage in mice predict abnormal strain distributions in osteoarthritis.

This study uses ultrasound and EMG to stratify carpal tunnel syndrome severity, finding that a simplified model of morphological and electrophysiological features improves diagnostic accuracy and reveals structure-function mismatches.

This paper develops an inversion pipeline using synchrotron tomography and digital volume correlation to estimate elastic properties of rat vertebral endplates, showing high spatial agreement between FEM predictions and experimental data.

This study uses imaging and modeling to show how structural changes in knee joints predict osteoarthritis onset by altering strain distribution.

This paper introduces TomoSAXS to map fibril-to-fibre mechanics in intervertebral discs and shows how pre-strain and strain variability correlate with mechanical behavior.