Santosh Kumar Gothwal

Distal super-enhancer drives aberrant CXCL13 expression in Cancer cells driving growth and p53 dysregulation via CXCR5-CXCL13 axis

This study identifies a distal super-enhancer near CCNG2 that drives aberrant CXCL13 expression in cancer cells, leading to growth promotion and p53 dysregulation via the CXCR5-CXCL13 axis.

Reduced B cell activation in Germinal center reaction of the mouse model of Li-Fraumeni syndrome

This study shows that p53 mutations in Li-Fraumeni syndrome mice reduce B cell activation during germinal center reactions without affecting the ratio of activated B cells in dark and light zones.

Isolation of region-specific factors assembled on the Immunoglobulin heavy chain locus during antibody class switch recombination

The paper isolates factors specific to the Immunoglobulin heavy chain locus involved in antibody class switch recombination by using a GAL4-based pulldown method.

DNA replication stress-induced transcriptome of Human Burkitt lymphoma identifies MBD1 as a novel suppressor of BCL6 rearrangements in germinal center derived B-lymphomagenesis

This study identifies MBD1 as a suppressor of BCL6 rearrangements in Burkitt lymphoma by regulating DNA methylation and genomic stability during DNA replication stress.

Stress Induced Signaling Pathways in Burkitt Lymphoma Play Novel Mechanisms in Fate Determination and Pathogenesis of Germinal Center-Derived B-Lymphomas

The paper investigates how stress-induced signaling pathways in Burkitt lymphoma affect B cell fate and lymphoma pathogenesis by analyzing gene regulation and transcriptional changes.