Jack P. Kucinski

This study investigates HES3's role in development and fusion-positive rhabdomyosarcoma using zebrafish models and finds HES3 regulates neural programs and interacts with PAX3::FOXO1 to influence tumor biology.

This paper compares the chromatin engagement mechanisms of PAX3::FOXO1 and PAX7::FOXO1 fusions in rhabdomyosarcoma using modified MNase ChIP and identifies distinct nucleosome targeting patterns.

The paper identifies PAX3::FOXO1's pioneer function through partial/homeobox motif recognition and its role in initiating neural transcriptional programs in rhabdomyosarcoma.

The paper introduces a low-cost, flexible method for quantitative chromatin sequencing and enables cross-species epigenomic comparisons.

This study generates and characterizes a zebrafish her3/HES3 knockout to examine its role in neural development and cancer-related pathways.