Benjamin Z. Stanton

This study identifies PAX3::FOXO1 and MYCN as cooperative regulators of MIR17HG expression in fusion-positive rhabdomyosarcoma and shows miR-17-92 is necessary for oncogenic activity.

This study shows Hat1 regulates H3K9 methylation and HMT localization in LADs, affecting heterochromatin structure and inheritance in mouse cells.

This paper compares the chromatin engagement mechanisms of PAX3::FOXO1 and PAX7::FOXO1 fusions in rhabdomyosarcoma using modified MNase ChIP and identifies distinct nucleosome targeting patterns.

This study investigates the role of Myc family proteins in FP-RMS, showing MYCN or MYC dominance in some cases and functional redundancy in others, with both contributing to oncogenic properties.

The paper uses CRISPR-Sirius to visualize differences in large-scale chromosome conformations between osteoblasts and osteosarcoma cells, revealing regulatory mechanisms involving H3K27me3 and CTCF/cohesin.

The paper identifies PAX3::FOXO1's pioneer function through partial/homeobox motif recognition and its role in initiating neural transcriptional programs in rhabdomyosarcoma.

The paper introduces a low-cost, flexible method for quantitative chromatin sequencing and enables cross-species epigenomic comparisons.

This study shows that varying levels of PAX3::FOXO1 protein affect cell state and epigenetic heterogeneity in rhabdomyosarcoma.

This study shows HAT1 acetylates new histones during DNA replication, regulating chromatin state inheritance and nuclear lamina-heterochromatin interactions.

This study investigates the chromatin-binding properties of the oncogenic PAX3-FOXO1 fusion protein using pc-ChIP-seq, revealing its pioneer function at repressed chromatin in RMS cells.

This study shows that the BAF complex both antagonizes and promotes polycomb-mediated repression by redistributing polycomb complexes across the genome in embryonic stem cells.